Tetrahydrofuran → HCID 14229389, compound

Participants

Reaction Steps

A mixture consisting of 3-(1-oxo-2-cyclohexen-3-yl)amino-4-cyanopyridine (3.3 g), potassium carbonate (2.35 g), cuprous chloride (153 mg) and 80 ml of tetrahydrofuran was refluxed for 1 hour. To the mixture was added 25 ml of methanol and the inorganics were removed by filtration. The filtrate liquid was then passed through a packed column and eluted with ethyl acetate to give 3.0 g of solid, mp 237°-242° C. This was recrystallized from n-butyl acetate to give 1.85 g of crystals, mp 242.5°-245° C.

Provenance & Evidence