反应详情

To a solution of 10.5 g (0.073 mole) of methyl 2-allylaminopropionate in 50 ml of toluene is added 15 g (0.08 mole) of 3,5-dichlorophenylisocyanate in small portions. The resulting mixture is heated to reflux for 2 hours. The reaction mixture is cooled and filtered. The filtrate is concentrated under vacuum to give 25 g of a yellow oil. This material is further purified by passing it through a silica gel column using 40/60 ethyl acetate/hexane as the solvent followed by trituration with hexane/ether to give 18 g of a light yellow solid., m.p. 78°-80°.

1. temperatureThe resulting mixture is heated
2. temperatureto reflux for 2 hours
3. temperatureThe reaction mixture is cooled
4. filtrationfiltered
5. concentrationThe filtrate is concentrated under vacuum