1,3-Dimethyl-5-ethoxycarbonylbarbituric acid → 1,3-Dimethyl-5-[4-(2-isopropyl-6-methylpyrimidin-4-yloxy)phenylcarbamoyl]barbituric acid

HRID 580538Notes

Reaction equation

HRID 580538 reaction equation
[CH3:1][N:2]1[C:9](=[O:10])[CH:8]([C:11]([O:13]CC)=O)[C:6](=[O:7])[N:5]([CH3:16])[C:3]1=[O:4].[CH:17]([C:20]1[N:25]=[C:24]([O:26][C:27]2[CH:33]=[CH:32][C:30]([NH2:31])=[CH:29][CH:28]=2)[CH:23]=[C:22]([CH3:34])[N:21]=1)([CH3:19])[CH3:18]>C1(C)C=CC=CC=1>[CH3:16][N:5]1[C:6](=[O:7])[CH:8]([C:11](=[O:13])[NH:31][C:30]2[CH:29]=[CH:28][C:27]([O:26][C:24]3[CH:23]=[C:22]([CH3:34])[N:21]=[C:20]([CH:17]([CH3:19])[CH3:18])[N:25]=3)=[CH:33][CH:32]=2)[C:9](=[O:10])[N:2]([CH3:1])[C:3]1=[O:4]

Participants

4

Reactant 2

HCID 5937141,3-Dimethyl-5-ethoxycarbonylbarbituric acidHCID 20133966HCID 20133966, compound

Product 1

HCID 201339651,3-Dimethyl-5-[4-(2-isopropyl-6-methylpyrimidin-4-yloxy)phenylcarbamoyl]barbituric acid

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

3.0 g (0.013 mole) of 1,3-dimethyl-5-ethoxycarbonylbarbituric acid and 3.2 g (0.013 mole) of 4-(2-isopropyl-6-methylpyrimidin-4-yloxy)aniline are suspended in 30 ml of toluene and heated for 18 hours at reflux temperature in an inert gas atmosphere (nitrogen). After cooling, the precipitate is isolated by filtration, washed with alcohol and dried.

Workup

  1. temperatureheated for 18 hours
  2. temperatureat reflux temperature in an inert gas atmosphere (nitrogen)
  3. temperatureAfter cooling
  4. customthe precipitate is isolated by filtration
  5. washwashed with alcohol
  6. customdried

Sources & evidence

ORD record
ord-974fd465a25540a196a510ec2c481ca6
Source dataset
uspto-grants-1988_06
Patent number
US04753940

Reaction notes

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