Hydrochloric Acid → HCID 14049970, compound

Participants

Reaction Steps

N-(4-fluoro-3-phenoxybenzyloxy)phthalimide 5 g, 14 mmol), n-butylamine (1.13 g, 15 mmol) and absolute ethanol (3 ml) were placed in a dry flask under a nitrogen atmosphere. This reaction mixture was stirred at 60°-75° for 1.5 hours, cooled and adjusted to pH 3 using dry hydrogen chloride gas. The solution was concentrated to 10 ml and poured into dry ether. The resulting white precipitate was filtered off and recrystallized from petroleum spirit (40°-60°)/dichloromethane to give 3.2 g (87%) of a white solid, m.p. 149.3°.

Provenance & Evidence