HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 4-Methyl-5-oxopyrrolidine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3-Pyrrolidinecarboxylic acid, 4-methyl-5-oxo-, ethyl ester | HCID 12292463 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Methyl-5-oxopyrrolidine-3-carboxamide | HCID 13933088 | — |
Reaction Steps
A solution of ethyl 3-methyl-2-oxo-4-pyrrolidinecarboxylate [Chem. Pharm. Bull., 24, 1362 (1976)] (5 g) in methanol (100 ml) saturated with ammonia gas left at room temperature for 4 days. After the reaction mixture was concentrated and the residue was recrystallized from ethanol to give 3-methyl-2-oxo-4-pyrrolidinecarboxamide (3.4 g), mp 169°-171° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04753953 |
| Source dataset | uspto-grants-1988_06 |
| ORD ID | ord-9fc8a084a49747b491d41c957fb333ee |
| Source note | uspto-grants-1988_06 |