HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → (5-Bromopyridin-3-YL)(4-methylpiperazin-1-YL)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 5-Bromonicotinic acid | HCID 88707 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (5-Bromopyridin-3-YL)(4-methylpiperazin-1-YL)methanone | HCID 23884265 | — |
Reaction Steps
5-Bromonicotinic acid (0.020 g, 0.10 mmol), 1-methylpiperazine (0.015 g, 0.15 mmol), HATU (0.046 g, 0.12 mmol), DIPEA (0.052 g, 0.40 mmol), and dioxane (2 mL) were added to a 20 mL vial. The vial was sealed and placed on a heater/shaker for 3 days at 40° C. The reaction mixture, containing the title compound, was used without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434743B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-8425fd72028f40bdad460916876c2b42 |
| Source note | uspto-grants-2016_09 |