1,2-Dichloroethane → 4-bromo-N-(2-hydroxyethyl)picolinamide

참여 물질

역할	이름	HCID	투입량
반응물	1,2-Dichloroethane	HCID 11	—
반응물	Ethanolamine	HCID 700	—
반응물	1-Hydroxybenzotriazole	HCID 75771	—
반응물	Diisopropylethylamine	HCID 81531	—
반응물	4-Bromopyridine-2-carboxylic acid	HCID 735150	—
용매	Dimethylformamide	HCID 6228	—
용매	Dichloromethane	HCID 6344	—
생성물	4-bromo-N-(2-hydroxyethyl)picolinamide	HCID 89781740	—

반응 단계

To 4-bromopicolinic acid (0.3 g, 1.485 mmol) in DMF (4 mL) were added 2-aminoethanol (0.181 g, 2.97 mmol), HOBt (0.301 g, 2.228 mmol), and EDC (0.456 g, 2.376 mmol), followed by N-ethyl-N-isopropylpropan-2-amine (1.293 mL, 7.43 mmol). The reaction mixture was stirred for 18 hours at room temperature. The reaction mixture was diluted with DCM, washed with brine, and concentrated to give the title compound, which was used without further purification.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09434743B2
출처 데이터셋	uspto-grants-2016_09
ORD ID	ord-7c297db1e83246e1a0f83a2fd9b37419
출처 메모	uspto-grants-2016_09