Sodium Carbonate → 4(2,4-dimethoxypyrimidin-5-yl)-6-(trifluoromethyl)-1H-indazole

Participants

Reaction Conditions

Reaction Steps

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)-1H-indazole (35 mg, 0.112 mmol), 5-bromo-2,4-dimethoxypyrimidine (24.56 mg, 0.112 mmol), and PdCl2(dppf) (8.21 mg, 0.011 mmol) were dispersed in dioxane (1.5 mL). To the resulting slurry was added 2N aqueous sodium carbonate (0.112 mL, 0.224 mmol). The mixture was purged with nitrogen, heated in a microwave reactor at 130° C. for 50 minutes, and then filtered through a microfiltration frit. Dioxane was stripped with nitrogen. The resulting residue was taken up in DMSO and methanol (1:1) and was purified via preparative HPLC, eluting with a gradient of ACN (containing 0.035% TFA) in H2O (containing 0.05% TFA). The purified fractions were collected to give a TFA salt of the title compound (8.2 mg, 23%). ESI-MS m/z [M+H]+ calc'd for C14H11F3N4O2, 325.1. found 325.2.

Provenance & Evidence