Cesium carbonate → HCID 86754149, compound

HRID 580804Notes

Reaction equation

HRID 580804 reaction equation
C(=O)([O-])[O-].[Cs+:5].[Cs+].[C:7]([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)(=[O:18])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16]>O.CO>[C:7]([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)(=[O:18])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]([O-:17])=[O:16].[Cs+:5]

Participants

4

Reactant 2

HCID 10796Cesium carbonateHCID 142502649-(Benzyloxy)-9-oxononanoic acid

Product 1

HCID 86754149HCID 86754149, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

Aqueous cesium carbonate (1M, 6.3 ml) is added dropwise to a solution of benzyl hydrogen azelate (3.00 g, 10.77 mmol) in 75 ml water/methanol (1:15) until the pH reaches approximately 7, whereupon the solvent is removed under reduced pressure and the residue dried under vacuum overnight. The oily, yellowish semicrystalline residue is dispersed in dry dimethylformamide (50 ml) and evaporated to dryness in vacuo. This procedure is repeated twice, yielding an off-white crystalline product. The product is used without further characterization.

Workup

  1. customwhereupon the solvent is removed under reduced pressure
  2. customthe residue dried under vacuum overnight
  3. additionThe oily, yellowish semicrystalline residue is dispersed in dry dimethylformamide (50 ml)
  4. customevaporated to dryness in vacuo
  5. customyielding an off-white crystalline product

Sources & evidence

ORD record
ord-06791c47a9ff46fcb0e73cf1ef963160
Source dataset
uspto-grants-1999_07
Patent number
US05919753

Reaction notes

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