HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 580822Generated: October 27, 2026
Ethylamine → 3-Bromo-2-(2-ethylaminopyridin-3-yl)thiophene
https://huagongshe.com/reaction/580822
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethylamine | HCID 6341 | — |
| Reactant | 3-Bromo-2-(2-fluoropyridin-3-yl)thiophene | HCID 15408568 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-Bromo-2-(2-ethylaminopyridin-3-yl)thiophene | HCID 15408569 | 87.3% |
Reaction Steps
A mixture of 3-bromo-2-(2-fluoropyridin-3-yl)thiophene (0.47 g) and ethylamine (0.4 g) in dioxane (2 mL) in a sealed tube was heated at 100° C. for 2 days. The mixture was diluted with ethyl acetate, washed with water, dried, filtered and evaporated to give 3-bromo-2-(2-ethylaminopyridin-3-yl)thiophene (0.45 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05919779 |
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| Source dataset | uspto-grants-1999_07 |
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| ORD ID | ord-f94f59eb677649d19609627f47746aa1 |
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| Source note | uspto-grants-1999_07 |
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