HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 580823Generated: October 31, 2026
2-Fluoro-3-(tributylstannyl)pyridine → 3-(2-Fluoropyridin-3-yl)-2-(2-ethylaminopyridin-3-yl)thiophene
https://huagongshe.com/reaction/580823
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Fluoro-3-(tributylstannyl)pyridine | HCID 11090319 | — |
| Reactant | 3-Bromo-2-(2-ethylaminopyridin-3-yl)thiophene | HCID 15408569 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 3-(2-Fluoropyridin-3-yl)-2-(2-ethylaminopyridin-3-yl)thiophene | HCID 15408570 | 31.2% |
Reaction Steps
A mixture of 3-bromo-2-(2-ethylaminopyridin-3-yl)thiophene (0.085 g), 2-fluoro-3-tributylstannylpyridine (0.26 g) and Pd(Ph3P)2Cl2 (0.014 g) in N-methylpyrrolidinone (2 mL) was heated at 75° C. under argon for 1 day. The mixture was diluted with ethyl acetate, washed, dried, filtered and evaporated. The residue was chromatographed to give 3-(2-fluoropyridin-3-yl)-2-(2-ethylaminopyridin-3-yl)thiophene (0.028 g). mp 86-89° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05919779 |
|---|
| Source dataset | uspto-grants-1999_07 |
|---|
| ORD ID | ord-400e687eb1fa41a78c0b0bd83bded3a1 |
|---|
| Source note | uspto-grants-1999_07 |
|---|
