Butyl nitrite → HCID 53662505, compound

Participants

Reaction Steps

To a solution of 4, 5-di-(2-chloropyridin-3-yl)-2-aminothiazole (0.060 g) in tetrahydrofuran (5 mL) was added butylnitrite (0.060 g). The mixture was heated under reflux for 3 hours. Further butylnitrite was added, and heating was continued for 2 hours. The solvent was evaporated, and the residue was fractionated by chromatography over silica gel to give 4, 5-di-(2-chloropyridin-3-yl)thiazole (0.035 g) as a solid.

Provenance & Evidence