Potassium bis(trimethylsilyl)amide → HCID 474627, compound

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Reaction Steps

To a solution of 4-(2-chloropyridin-3-yl)-5-(2-ethylaminopyridin-3-yl)-1, 2, 3-thiadiazole (0.700 g) in tetrahydrofuran (5 mL) was added potassium bistrimethylsilylamide (0.5M in toluene, 3.5 mL). After 10 minutes the mixture was diluted with ethyl acetate, washed with water, dried, filtered and evaporated. Chromatography of the residue over silica gel gave 8-ethyl-(1, 2, 3)thiadiazolo[4',5':6,5]dipyrido[2,3-b:3',2'-f]azepine (0.453 g). mp 194-196° C.

Provenance & Evidence