2-Chloropyridine → 4-Piperidinemethanol,1-(4-pyridinyl)-

HRID 580855Notes

Reaction equation

Cl[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[OH:8][CH2:9][CH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>>[OH:8][CH2:9][CH:10]1[CH2:15][CH2:14][N:13]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=2)[CH2:12][CH2:11]1

Participants

Reactant 2

HCID 79772-Chloropyridine

HCID 4207714-Piperidinemethanol

Product 1

HCID 107741274-Piperidinemethanol,1-(4-pyridinyl)-Yield 80.9%

Procedure

The title compound (2.7 g, 80%) was prepared as a syrupy liquid from 2-chloropyridine (7.8 g) and 4-hydroxymethylpiperidine (2 g) by an analogous procedure to that described in preparation 1.

Workup

customthat described in preparation 1

Sources & evidence

ORD record: ord-b7026d13a6914bb5a964a34fcba2997b
Source dataset: uspto-grants-1999_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05919782

Reaction notes

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