2-Chloroquinoline → HCID 10513555, compound

HRID 580857Notes

Reaction equation

HRID 580857 reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH:12]1[CH2:18][CH2:17][CH2:16][C@H:13]1[CH2:14][OH:15]>>[OH:15][CH2:14][C@@H:13]1[CH2:16][CH2:17][CH2:18][N:12]1[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 119282-ChloroquinolineHCID 640091L-Prolinol

Product 1

HCID 10513555HCID 10513555, compoundYield 107.5%

Procedure

The title compound (6 g, 100%) was prepared as a syrupy liquid from 2-chloroquinoline (4 g) and L-prolinol (14.8 g) by an analogous procedure to that described in preparation 1.

Workup

  1. customthat described in preparation 1

Sources & evidence

ORD record
ord-65ac8b89facd41658929a18f8a49812e
Source dataset
uspto-grants-1999_07
Patent number
US05919782

Reaction notes

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