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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 580858Generated: October 25, 2026

2-Chloro-4-methylquinoline → (S)-2-Hydroxymethyl-1-(lepidin-2-yl)pyrrolidine

https://huagongshe.com/reaction/580858

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-4-methylquinolineHCID 69449—
ReactantL-ProlinolHCID 640091—
Product(S)-2-Hydroxymethyl-1-(lepidin-2-yl)pyrrolidineHCID 1084775894%

Reaction Steps

The title compound (22 g, 94%) was prepared as thick liquid from 2-chlorolepidine (17.3 g) and L-prolinol (59 g) by an analogous procedure to that described in preparation 1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05919782
Source datasetuspto-grants-1999_07
ORD IDord-33d5af3892b544d3a8fc3da23debd946
Source noteuspto-grants-1999_07