3-Pyridinemethanamine → HCID 178477856, compound

Participants

Reaction Steps

A solution of 0.41 g (1.57 mmol) of 7-chloro-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-thione (Hunziker F., et al., Helv. Chim. Acta, 50:1588 (1967)) in 10 mL 2-ethoxyethanol was treated with 0.32 mL (3.14 mmol) of 3-(aminomethyl)pyridine and heated at reflux for 22 hours. The solvent was removed under reduced pressure and the residue mixed with EtOAc and filtered to give 0.31 g of product. The filtrate was concentrated and chromatographed on silica gel, eluting with EtOAc to give an additional 0.16 g of product. The material was combined and recrystallized from EtOAc/hexane to give 0.3 g (56.6% yield) of the product as a pale yellow solid, mp 218-220° C. The structure was confirmed by NMR and mass spectroscopy. (m+H)+ =335.

Provenance & Evidence