HCID 15389009, compound → HCID 15406844, compound

Participants

Reaction Steps

1-[(2-Dimethylaminoethyl)aminocarbonyl]-5,6-dimethyl-9-hydroxy-10-propyl-6H-pyrido-[4,3-b]carbazole ##STR26## 0.7 g of 1-ethoxycarbonyl-5,6-dimethyl-9-hydroxy-10-allyl-6H-pyrido[4,3-b]carbazole is hydrogenated in 200 ml of ethanol in the presence of 0.3 g of 10% palladium-on-carbon at 40° C. under a hydrogen pressure of 1.105Pa for 30 minutes. Filtration is carried out, the catalyst is washed with ethanol and the combined filtrates are concentrated to dryness. The residue is chromatographed on silica using as eluant first dichloromethane and then a dichloromethane/ethanol mixture (98/2). 0.362 g of 1-ethoxycarbonyl-5,6-dimethyl-9-hydroxy-10-propyl-6H-pyrido[4,3-b]carbazole is obtained. Yield: 51%.

Provenance & Evidence