1,2-Dichloroethane → HCID 70275469, compound

Participants

Reaction Steps

A solution of acid 5-6 (400 mg, 1.43 mmol), amine 5-4 (686 mg, 1.57 mmol), EDC (358 mg, 1.86 mmol), HOBT (252 mg, 1.86 mmol), NMM (632 μl, 5.72 mmol) and DMF (10 ml) was stirred for ~20 h. The reaction was diluted with EtOAc and then washed with sat NaHCO3, brine, dried (MgSO4) and concentrated. Flash chromatography (silica, EtOAC to 5% isopropanol/EtOAc) provided amide 5-7 as a white solid.

Provenance & Evidence