反应详情

Next, 0.33 g of 5,6,7,8-tetrahydro-2-(4-nitrophenyl)-3-formylimidazo[2,1-b]benzothiazole, 0.15 g of nicotinohydrazide, and 0.1 g of potassium hydroxide were heated and stirred in 20 ml of methanol at 90° C. for 1.5 hours. After cooling, the solvent was distilled off under reduced pressure and the residue was extracted with chloroform. The extract was washed with water and dried, then the solvent was distilled off and the residue was crystallized from methanol to obtain the desired substance in an amount of 0.25 g (yield of 55.6%).

1. temperatureAfter cooling
2. distillationthe solvent was distilled off under reduced pressure
3. extractionthe residue was extracted with chloroform
4. washThe extract was washed with water
5. customdried
6. distillationthe solvent was distilled off
7. customthe residue was crystallized from methanol
8. customto obtain the desired substance in an amount of 0.25 g (yield of 55.6%)