2-(2-(Hydroxymethyl)-5-nitrophenyl)ethanol → 2-(5-Amino-2-hydroxymethylphenyl)-ethanol

Participants

Reaction Steps

Pt-C (50% water wet, 200 mg) was added to a THF (40 mL) solution of 2-(2 hydroxymethly-5-nitro-phenyl)-ethanol (1.0 g, 5 mmol) and the reaction hydrogenated at 50 psi for 2 hrs. NMR showed complete reaction to form 2-(5-amino-2-hydroxymethyl-phenyl)-ethanol (compound (9) in Scheme 3);

Provenance & Evidence