1-(4-Benzyloxy-phenyl)-5-trifluoromethyl-1H-tetrazole → 4-(5-Trifluoromethyl-tetrazol-1-YL)-phenol

Participants

Reaction Steps

A solution of 1-(4-benzyloxy-phenyl)-5-trifluoromethyl-1H-tetrazole (45.3 mmol) in ethanol (100 ml) and tetrahydrofuran (100 ml) was hydrogenated at room temperature and atmospheric pressure over 10% palladium-carbon catalyst (6 g). After 2 h, the mixture was filtered and the filtrate was evaporated to give the title compound (10.4 g) as a cream solid.

Provenance & Evidence