Hydrochloric Acid → HCID 21310029, compound

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Reaction Steps

From 3-{tert-butoxycarbonyl-[2-(1-butoxy)-5-(5-trifluoromethyl-tetrazol-1-yl)-benzyl]-amino}-[2S,3S]-2-phenylpiperidine-1-carboxylic acid tert-butyl ester (345 mg, 0.51 mmol) using 4M-hydrogen chloride in dioxan (5 ml) at 40° C. to give the title compound as a white crystals from ethanol (218 mg). Found C, 51.78; H, 5.62; N, 15.13; C24H29F3N6O.2HCl.0.5H2O (556.46), requires C,51.80; H, 5.80; N, 15.10%. Mass spectrum (thermospray +ve) m/e 475 (MH+).

Provenance & Evidence