Diphenyl Ether → HCID 57209852, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 4-allyloxyphenylmethyloxyacetate (2.00 g) and diphenyl ether (14 ml) was heated at 200° C. in an atmosphere of argon for 9 hours. The mixture was cooled to ambient temperature and purified by flash column chromatography on silica gel using a 4:1 (v/v) mixture of hexane and ethyl acetate as eluent to give methyl (3-allyl-4-hydroxyphenyl)methyloxyacetate (435 mg) as a colourless oil; NMR(CDCl3): 3.38(2H,d), 3.75(3H,s), 4.07(2H,s), 4.52(2H,s), 5.12(2H,m), 6.00(1H,m), 6.78(1H,m) and 7.08(2H,m); m/z 236(M).

Provenance & Evidence