Ammonia → 2-(4-Iodophenyl)acetamide

HRID 581000Notes

Reaction equation

HRID 581000 reaction equation
[NH3:1].[I:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10](Cl)=[O:11])=[CH:5][CH:4]=1>CCOCC>[I:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([NH2:1])=[O:11])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 13340573HCID 13340573, compound

Product 1

HCID 130308042-(4-Iodophenyl)acetamide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Concentrated aqueous ammonia (density, 0.88 g/cm3) was added to a solution of 4-iodophenylacetyl chloride (2.80 g) in ether (30 ml) and the mixture was stirred at ambient temperature for 15 minutes. The product, 4-iodophenylacetamide, was obtained as a colourless crystalline solid (2.36 g), m.p: 200-204° C.; NMR: 3.34(2H,s), 6.87(H,bs), 7.44(2H,bs), 7.04-7.68(4H,AB); m/z 262(M+H).

Sources & evidence

ORD record
ord-740f718f85734f74811c2adfaa9cbaf9
Source dataset
uspto-grants-1999_07
Patent number
US05919793

Reaction notes

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