反应详情

A solution of 1.25 g (5 mmol) of 4-methoxy-2-methyl-1-(phenylmethyl)-1H-indole and 20 mL of 1M BBr3 /CH2Cl2 in 50 mL of methylene chloride was stirred at room temperature for 5 hours and concentrated at reduced pressure. The residue was dissolved in ethyl acetate, washed with brine and dried (MgSO4). After concentrating at reduced pressure, the residue was chromatographed on silica gel eluting with 20% EtOAc/hexane to give 577 mg (49% yield) of 4-hydroxy-2-methyl-1-(phenylmethyl)-1H-indole, 125-127° C.

1. concentrationconcentrated at reduced pressure
2. dissolutionThe residue was dissolved in ethyl acetate
3. washwashed with brine
4. dry with materialdried (MgSO4)
5. concentrationAfter concentrating at reduced pressure
6. customthe residue was chromatographed on silica gel eluting with 20% EtOAc/hexane