HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 10806128, compound → 1-([1,1'-biphenyl]-4-ylmethyl)-4-hydroxy-2-methyl-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 10806128 | HCID 10806128 | — |
| Reactant | Boron tribromide dichloromethane | HCID 22277759 | — |
| Product | 1-([1,1'-biphenyl]-4-ylmethyl)-4-hydroxy-2-methyl-1H-indole | HCID 10495409 | 77.4% |
Reaction Steps
By the method used in Example 1, Part D, 1.3 g (4.0 mmol) of 1-([1,1'-biphenyl]-4-ylmethyl)-4-methoxy-2-methyl-1H-indole was O-demethylated by treating it with 16 mL of 1M BBr3 /CH2Cl2 to give 970 mg (77% yield) of crude 1-([1,1'-biphenyl]-4-ylmethyl)-4-hydroxy-2-methyl-1H-indole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05919810 |
| Source dataset | uspto-grants-1999_07 |
| ORD ID | ord-22c6b1c0382e456bb8f9c5265f5458f4 |
| Source note | uspto-grants-1999_07 |