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1-(2-(Tert-butoxycarbonylamino)-5-methoxyphenyl]-2-butanone → 2-ethyl-5-methoxy-1H-indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(2-(Tert-butoxycarbonylamino)-5-methoxyphenyl]-2-butanone | HCID 10517825 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Trifluoroacetic acid | HCID 6422 | — |
| 生成物 | 2-ethyl-5-methoxy-1H-indole | HCID 10702405 | 58% |
反応手順
1-[2-(tert-Butoxycarbonylamino)-5-methoxyphenyl]-2-butanone (7.33 g, 0.025 mol) in 120 mL of CH2Cl2 and 20 mL of trifluoroacetic acid was stirred for 20 hours, washed with water, NaHCO3 solution and the product chromatographed on silica (eluted with 20% EtOAc/hexane) to give 2.54 g (58% yield) of 2-ethyl-5-methoxy-1H-indole as a white solid, mp 49-50° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05919810 |
| 出典データセット | uspto-grants-1999_07 |
| ORD ID | ord-9367416cee5545bfb87b7a04cd115668 |
| 出典メモ | uspto-grants-1999_07 |