HCID 57054725, compound → 3-(8-Methyl-8-azabicyclo[3.2.1]octan-3-yl)aniline

Participants

Reaction Steps

8-Methyl-3-(3-nitrophenyl)-8-azabicyclo[3.2.1]oct-2-ene (D10) (0.146 g, 0.598 mmol) was dissolved in ethanol (25 ml) and was hydrogenated at atmospheric pressure in the presence of 10% PdC (0.1 g) at 50° C. After 2 h, the reaction mixture was allowed to cool to room temp. and hydrogenation was continued for a further 16 h. The reaction mixture was then filtered through kieselguhr and the filter pad was washed with ethanol. The filtrate was then evaporated under reduced pressure to give the title compound as a pale yellow oil, which was dried in vacuo (0.104 g, 81%).

Provenance & Evidence