3-Chlorothiophene-2-carbonyl chloride → 5-(N-[3-chloro-2-thiophenecarbonyl]amino)-3-(1-methylpiperidin-4-yl)pyrrolo[3,2-b]pyridine

Participants

Role	Name	HCID	Charge
Reactant	3-Chlorothiophene-2-carbonyl chloride	HCID 2735824	—
Reactant	3-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-ylamine	HCID 10220230	—
Product	5-(N-[3-chloro-2-thiophenecarbonyl]amino)-3-(1-methylpiperidin-4-yl)pyrrolo[3,2-b]pyridine	HCID 19601541	57.5%

Reaction Steps

Beginning with 0.30 gm (1.3 mMol) 5-amino-3-(1-methylpiperidin-4-yl)pyrrolo[3,2-b]pyridine and 0.29 gm (1.56 mMol) 3-chloro-2-thiophenecarbonyl chloride, 0.28 gm (57%) of the title compound were prepared as an orange foam essentially by the procedure described in Example 4.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05919936
Source dataset	uspto-grants-1999_07
ORD ID	ord-a078e47f7cf14812b022975dac96742c
Source note	uspto-grants-1999_07