Phosphorus trichloride → HCID 10861138, compound

Participants

Reaction Steps

reacting 4,4-diphenylcyclohexanol with PCl3 to obtain 4,4-diphenylcyclohexyloxy dichlorophosphine having the formula: ##STR16## (b) coupling the 4,4-diphenylcyclohexyloxy-dichlorophosphine formed in step (a) with an amine base to obtain 4,4-diphenylcyclohexyloxydiaminophosphine having the formula: ##STR17## (c) coupling of the 4,4-diphenylcyclohexyloxy-diaminophosphine formed in step (b) with hydroxymethyl-DTPA penta tert-butyl ester to obtain 4,4-diphenylcyclohexyloxy (hydroxymethyl-DTPA -oxy, penta tert-butyl ester)amino-phosphine having the formula: ##STR18## (d) hydrolysis and oxidation of the 4,4-diphenylcyclohexyloxy (hydroxymethyl-DTPA oxy, penta tert butyl ester) aminophosphine formed in step (c) with dilute HCl and an oxidant to form (4,4-diphenylcyclohexyl)phosphonooxymethyl diethylene triamine, penta t-butyl ester having the formula: ##STR19##

Provenance & Evidence