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1-([1,1'-biphenyl]-3-ylmethyl)-4-methoxy-2-methyl-1H-indole → HCID 10495408、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-([1,1'-biphenyl]-3-ylmethyl)-4-methoxy-2-methyl-1H-indole | HCID 10758603 | — |
| 反応物 | Boron tribromide dichloromethane | HCID 22277759 | — |
| 生成物 | HCID 10495408 | HCID 10495408 | 87% |
反応手順
By the method used in Example 1, Part D, 1.25 g (3.8 mmol) of 1-([1,1'-biphenyl]-3-ylmethyl)-4-methoxy-2-methyl-1H-indole was O-demethylated by treating it with 15.2 mL of 1M BBr3 /CH2Cl2 to give 1.03 g (87% yield) of crude 1-([1,1'-biphenyl]-3-ylmethyl)-4-hydroxy-2-methyl-1H-indole.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05919943 |
| 出典データセット | uspto-grants-1999_07 |
| ORD ID | ord-d09766fdb3304269ba85d82724b5a7a9 |
| 出典メモ | uspto-grants-1999_07 |