Formic Acid → N-tert.-butyl-2-dimethylaminocarbonyl-5-formylaminobenzenesulfonamide

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.34 ml of formic acid and 0.70 ml of acetic anhydride is heated at 50° C. for 2 hours, and a solution of 0.85 g of 5-amino-N-tert.-butyl-2-dimethylaminocarbonyl-benzenesulfonamide (Example e) and 3.5 ml of dimethylformamide (DMF) is added. After 4 hours, the mixture is taken up in ethyl acetate and washed successively with dilute hydrochloric acid and saturated NaHCO3 solution. After the mixture has been dried over MgSO4 and the organic phase has been concentrated, 0.88 g of a highly viscous substance, which is used in subsequent reactions without further purification (Example j), is obtained.

Provenance & Evidence