HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-{[[4-[3-(4-Benzylpiperazin-1-yl)propylthio]-3-methoxy-2-pyridinyl]-methyl]thio}-1H-benzimidazole trihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-Benzylpiperazine | HCID 75994 | — |
| Reactant | 2-{[[4-(3-chloropropylthio)-3-methoxy-2-pyridinyl]methyl]thio}-1H-benzimidazole | HCID 54054490 | — |
| Product | 2-{[[4-[3-(4-Benzylpiperazin-1-yl)propylthio]-3-methoxy-2-pyridinyl]-methyl]thio}-1H-benzimidazole trihydrochloride | HCID 86754202 | 59% |
Reaction Steps
According to the procedure indicated in Examples 1), 3) and 6), reaction of 2-{[[4-(3-chloropropylthio)-3-methoxy-2-pyridinyl]methyl]thio}-1H-benzimidazole with N-benzylpiperazine and subsequent conversion into the hydrochloride gives the title compound; m.p. 180° C., dec.; colorless crystals; yield 59% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05922720 |
| Source dataset | uspto-grants-1999_07 |
| ORD ID | ord-12b6f137c03b4614aaa0149065c8da2b |
| Source note | uspto-grants-1999_07 |