1-Benzylpiperazine → HCID 178431908, compound

HRID 581740Notes

Reaction equation

HRID 581740 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][S:5][C:6]1[CH:11]=[CH:10][N:9]=[C:8]([CH2:12][S:13][C:14]2[NH:18][C:17]3[CH:19]=[CH:20][C:21]([F:23])=[CH:22][C:16]=3[N:15]=2)[C:7]=1[CH3:24].[CH2:25]([N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[ClH:1].[ClH:1].[CH2:25]([N:32]1[CH2:37][CH2:36][N:35]([CH2:2][CH2:3][CH2:4][S:5][C:6]2[CH:11]=[CH:10][N:9]=[C:8]([CH2:12][S:13][C:14]3[NH:18][C:17]4[CH:19]=[CH:20][C:21]([F:23])=[CH:22][C:16]=4[N:15]=3)[C:7]=2[CH3:24])[CH2:34][CH2:33]1)[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

Participants

3

Reactant 2

HCID 759941-BenzylpiperazineHCID 178431907HCID 178431907, compound

Product 1

HCID 178431908HCID 178431908, compoundYield 80%

Procedure

According to the procedure indicated in Example 1), reaction of 2-{[[4-(3-chloropropylthio)-3-methyl-2-pyridinyl]methyl]thio}-5-fluoro-1H-benzimidazole with N-benzylpiperazine gives the title compound as a beige powder. Yield 80%, m.p. 130-133° C.

Sources & evidence

ORD record
ord-5f9ba84205ff45d2a3fa312c097ee599
Source dataset
uspto-grants-1999_07
Patent number
US05922720

Reaction notes

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