HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malonic Acid → (E)-3-(6-Acetamidopyridin-3-YL)acrylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | N-(5-Formylpyridin-2-yl)acetamide | HCID 22113222 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | (E)-3-(6-Acetamidopyridin-3-YL)acrylic acid | HCID 10703461 | 81.9% |
Reaction Steps
A mixture of 2-acetylamino-5-formylpyridine (241 mg) and malonic acid (168 mg) in pyridine (0.12 ml) and ethanol (0.36 ml) was refluxed for 2 hours. After cooling the mixture, the precipitate was collected by filtration, and washed with ethyl acetate to give (E)-3-(6-acetylamino-3-pyridyl)acrylic acid (248 mg) as a colorless powder. mp: 291-2920° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05922711 |
| Source dataset | uspto-grants-1999_07 |
| ORD ID | ord-a2977919b0654270b5d9e948b1dd9aab |
| Source note | uspto-grants-1999_07 |