HRID581799

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CNC(=O)c1ccc(C=CC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1

HCID54496054

未命名化合物

HCID73950302

未命名化合物

PRODUCTS

生成物

HCID1118

Sulfuric acid

H2O4S

HCID54496054

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

CONDITIONS

反应条件

温度: 90 °C

PROCEDURE

实验过程

To a suspension of 8-[2,6-dichloro-3-[N-methyl-N-[4-(methylcarbamoyl)cinnamoylglycyl]amino]benzyloxy]-2-methylquinoline (225 mg) in ethanol (2.3 ml) was added 1N sulfuric acid-ethanol solution (0.38 ml) at ambient temperature, and the mixture was warmed at 90° C. and then stirred for 1 hour at ambient temperature. The resulting precipitate was collected by filtration, and the residue was dissolved in methylene chloride-methanol (10:1). The solvent was removed in vacuo to give 1/2 sulfuric acid salt of 8-[2,6-dichloro-3-[N-methyl-N-[4-(methylcarbamoyl)cinnamoylglycyl]amino]benzyloxy]-2-methylquinoline (210 mg).

WORKUP

后处理

filtrationThe resulting precipitate was collected by filtration
dissolutionthe residue was dissolved in methylene chloride-methanol (10:1)
customThe solvent was removed in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a1181867541e4d46a964e6089d630554
来源数据集: uspto-grants-1999_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05922711
来源说明: uspto-grants-1999_07

反应 SMILES

[Cl:1][C:2]1[C:20]([N:21]([CH3:40])[C:22](=[O:39])[CH2:23][NH:24][C:25](=[O:38])[CH:26]=[CH:27][C:28]2[CH:33]=[CH:32][C:31]([C:34](=[O:37])[NH:35][CH3:36])=[CH:30][CH:29]=2)=[CH:19][CH:18]=[C:17]([Cl:41])[C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:15]=1[N:14]=[C:13]([CH3:16])[CH:12]=[CH:11]2.[S:42](=[O:46])(=[O:45])([OH:44])[OH:43].C(O)C>C(O)C>[S:42](=[O:44])(=[O:43])([OH:46])[OH:45].[Cl:1][C:2]1[C:20]([N:21]([CH3:40])[C:22](=[O:39])[CH2:23][NH:24][C:25](=[O:38])[CH:26]=[CH:27][C:28]2[CH:29]=[CH:30][C:31]([C:34](=[O:37])[NH:35][CH3:36])=[CH:32][CH:33]=2)=[CH:19][CH:18]=[C:17]([Cl:41])[C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:15]=1[N:14]=[C:13]([CH3:16])[CH:12]=[CH:11]2