HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl bromoacetate → ethyl N-(4-fluorophenyl)glycine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | 4-Fluoroaniline | HCID 9731 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 18-Crown-6 | HCID 28557 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | ethyl N-(4-fluorophenyl)glycine | HCID 61998283 | — |
Reaction Steps
4-Fluoroaniline (5 g), potassium carbonate (3.11 g) and a catalytic amount of 18-Crown-6 were stirred together in 50 ml of ethanol. A solution of ethylbromoacetate (7.52 g) in 25 ml of ethanol was added dropwise and the reaction was heated to reflux.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05246933 |
| Source dataset | uspto-grants-1993_09 |
| ORD ID | ord-d5edec4fc25d4165a206856d008fcc0a |
| Source note | uspto-grants-1993_09 |