反应详情

A suspension of methyl 2-chloro-6-fluoro-3,5-dimethoxybenzoate (2.7 g, 0.010 mol) and sodium hydroxide (1.088 g, 0.0272) in anhydrous ethanol (30 mL) was refluxed for 24 h. The resulting reaction mixture was cooled to room temperature and concentrated under vacuum to get a crude residue. The crude residue was dissolved in water and extracted with ether (3×30 mL). The aqueous layer was acidified with conc.HCl and the precipitated solid was filtered, washed with cold water and dried in vacuo to afford the title compound (1.8 g, yield: 71%) as a solid.

1. temperaturewas refluxed for 24 h
2. customThe resulting reaction mixture
3. concentrationconcentrated under vacuum
4. customto get a crude residue
5. extractionextracted with ether (3×30 mL)
6. filtrationHCl and the precipitated solid was filtered
7. washwashed with cold water
8. customdried in vacuo