反应详情

A solution of N-benzyl-2-aminoethanol (12, 79.05 g, 0.523 mole) in chloroform (400 niL) was treated with thionyl chloride (80 mL, 1.09 mole) at room temperature. The resulting mixture was heated to reflux (6 h). The solvent was removed in vacuo, the residue dissloved in hot ethanol (1.3 L) and cooled overnight. The solids were collected via suction filtration and dried in vacuo at 65° C. (24 h) to afford the title compound 13 as white plates.

1. temperatureThe resulting mixture was heated
2. temperatureto reflux (6 h)
3. customThe solvent was removed in vacuo
4. temperaturecooled overnight
5. filtrationThe solids were collected via suction filtration
6. customdried in vacuo at 65° C. (24 h)