2-(Trifluoromethyl)thiophene → 4-Chloro-6-methoxy-2-(5-trifluoromethyl-2-thienyl)pyrimidine

Participants

Reaction Conditions

Reaction Steps

2.05 g 2-Trifluoromethylthiophene in 20 mL diethylether are treated with 8.2 mL of a 1.6 M solution of n-butyllithium in hexane at -70° C. After 30 minutes the mixture is warmed to -40° C. and added dropwise to a solution of 2,4-dichloro-6-methoxypyrimidine in 20 mL of ether, which is kept at 0° C. The mixture is allowed to reach room temperature, is washed with water and 0.24 g of the product are isolated as an oil after flash chromatography.

Provenance & Evidence