Benzyl 4-methoxycarbonylmethyloxyphenylacetate → 4-(2-Methoxy-2-oxoethoxy)-benzeneacetic acid

Participants

Reaction Steps

7.8 g (0.025 mol) of benzyl 4-methoxycarbonylmethyloxy-phenyl-acetate are hydrogenated exhaustively in 150 ml of methanol in the presence of 8 g of palladium hydroxide-on-charcoal at room temperature under a hydrogen pressure of 50 psi. After removal of the catalyst, the mother liquor is concentrated to dryness under reduced pressure. 4.7 g (89.5% of theory) of a resinous crude product remain.

Provenance & Evidence