5-Ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione → 1-(Cyclopent-3-en-1-ylmethyl)-6-(3,5-dimethylphenoxy)-5-ethyl-pyrimidine-2,4-dione

HRID 581863Notes

Reaction equation

HRID 581863 reaction equation
[CH2:1]([C:3]1[C:4](=[O:19])[NH:5][C:6](=[O:18])[NH:7][C:8]=1[O:9][C:10]1[CH:15]=[C:14]([CH3:16])[CH:13]=[C:12]([CH3:17])[CH:11]=1)[CH3:2].C1(C)C(S(O[CH2:30][CH:31]2[CH2:35][CH:34]=[CH:33][CH2:32]2)(=O)=O)=CC=CC=1>>[CH:31]1([CH2:30][N:7]2[C:8]([O:9][C:10]3[CH:11]=[C:12]([CH3:17])[CH:13]=[C:14]([CH3:16])[CH:15]=3)=[C:3]([CH2:1][CH3:2])[C:4](=[O:19])[NH:5][C:6]2=[O:18])[CH2:35][CH:34]=[CH:33][CH2:32]1

Participants

3

Reactant 2

HCID 109232665-Ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedioneHCID 86754218HCID 86754218, compound

Product 1

HCID 4745951-(Cyclopent-3-en-1-ylmethyl)-6-(3,5-dimethylphenoxy)-5-ethyl-pyrimidine-2,4-dioneYield 49.9%

Procedure

5-Ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione and (cyclopent-3-en-1-yl)methyl toluenesulfonate were reacted by the same method with the example 1 to obtain the titled compound (68 mg).

Sources & evidence

ORD record
ord-5d134737e55d43d4993810ba7227fc39
Source dataset
uspto-grants-1999_07
Patent number
US05922727

Reaction notes

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