5-Isopropyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedione → 1-(2-Cyclopent-2-en-1-ylethyl)-6-(3,5-dimethylphenyl)sulfanyl-5-isopropyl-pyrimidine-2,4-dione

HRID 581887Notes

Reaction equation

HRID 581887 reaction equation
[CH:1]([C:4]1[C:5](=[O:20])[NH:6][C:7](=[O:19])[NH:8][C:9]=1[S:10][C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[CH:12]=1)([CH3:3])[CH3:2].[CH:21]1([CH2:26][CH2:27]Br)[CH2:25][CH2:24][CH:23]=[CH:22]1>>[CH:21]1([CH2:26][CH2:27][N:8]2[C:9]([S:10][C:11]3[CH:12]=[C:13]([CH3:18])[CH:14]=[C:15]([CH3:17])[CH:16]=3)=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:20])[NH:6][C:7]2=[O:19])[CH2:25][CH2:24][CH:23]=[CH:22]1

Participants

3

Reactant 2

HCID 104937275-Isopropyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedioneHCID 126588663-(2-Bromoethyl)cyclopent-1-ene

Product 1

HCID 452733651-(2-Cyclopent-2-en-1-ylethyl)-6-(3,5-dimethylphenyl)sulfanyl-5-isopropyl-pyrimidine-2,4-dioneYield 25.5%

Procedure

5-Isopropyl-6-(3,5-dimethylphenylthio)-2,4-pyrimidinedione and 2-(cyclopent-2-en-1-yl)ethyl bromide were reacted by the same method with example 40 to obtain the titled compound (98 mg).

Sources & evidence

ORD record
ord-b7ef65b4a7f24a00baaf4b2f0cc11a04
Source dataset
uspto-grants-1999_07
Patent number
US05922727

Reaction notes

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