Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lithium iodide | HCID 66321 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 6-(3,5-dimethylbenzoyl)-5-ethylpyrimidine-2,4(1H,3H)-dione | HCID 22256579 | — |
| Reactant | HCID 86754222 | HCID 86754222 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 69976464 | HCID 69976464 | 24.5% |
Reaction Steps
A mixture of sodium bicarbonate (0.10 g, 1.2 mmol) and lithium iodide (13 mg, 0.1 mmol) were added to dimethylformamide solution (10 ml) of 5-ethyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione (0.27 g, 1.0 mmol) and 2-(cyclopentyl)ethyl toluenesulfonate (0.27 g, 1.0 mmol). And then, the reaction mixture was stirred at 90° C. for overnight, concentrated for removement of dimethylformamide, extracted with dichloromethane, dried, filtered and separated by column chromatography to give a white solid (90 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05922727 |
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| Source dataset | uspto-grants-1999_07 |
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| ORD ID | ord-9b5319a6902f4510aa054f4245b7aca6 |
|---|
| Source note | uspto-grants-1999_07 |
|---|
