O-ethylhydroxylamine hydrochloride → HCID 73769685, compound

Participants

Reaction Conditions

Reaction Steps

32a from Example 5 (5 g, 15.97 mmol) is suspended in absolute ethanol (50 ml) and heated to 70° C. O-Ethyl hydroxylamine hydrochloride (2.4 g, 24.61 mmol) is added and the mixture is heated to reflux for 1.5 hours. After cooling the solvent is removed by evaporation, and the residue is stirred with aqueous sodium hydroxide (50 ml, 1 M). The crude product is filtered off. Column-chromatographic workup on silica gel using a mixture of ethyl acetate and ethanol (9:1) as the eluent affords pure 33a. Yield: 3.7 g (65%). Mp 105-106° C.

Provenance & Evidence