Formic Acid → HCID 53940744, compound

Participants

Reaction Conditions

Reaction Steps

Raney Ni (2.0 g) was added to a solution of (54) (1.5 g, 4.9 mmol) in HCO2H (18 ml) and water (6 ml). The mixture was stirred under argon at 110° C. for 1 hr. After cooling the mixture was filtered. The filtrate was concentrated, partitioned between a 5% aqueous NaHCO3 solution and ethyl acetate. The organic phase was washed with brine, dried and concentrated under reduced pressure to give (55) (1.3 g, 87%).

Provenance & Evidence