Acetic Anhydride → HCID 47215507, compound

HRID 581928Notes

Reaction equation

HRID 581928 reaction equation
[N:1]1([C:6]2[CH:7]=[C:8]([CH:10]=[CH:11][CH:12]=2)[NH2:9])[CH:5]=[CH:4][N:3]=[CH:2]1.[OH-].[Na+].[C:15](OC(=O)C)(=[O:17])[CH3:16]>>[C:15]([NH:9][C:8]1[CH:10]=[CH:11][CH:12]=[C:6]([N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)[CH:7]=1)(=[O:17])[CH3:16]

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 14798Sodium HydroxideHCID 3212253-(1H-imidazol-1-yl)aniline

Product 1

HCID 47215507HCID 47215507, compoundYield 85%

Procedure

2d (5.88 g, 37 mmol) is stirred in acetic anhydride (30 ml) at ambient temperature for 1 hour. The mixture is poured into ice-water and rendered alkaline by addition of aqueous sodium hydroxide (12M). The product is filtered off, washed with water and dried to yield 2e (6.34 g, 85%). Mp 181-183° C.

Workup

  1. filtrationThe product is filtered off
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-0057fa1fcd84476c971b114d2e31df19
Source dataset
uspto-grants-1999_07
Patent number
US05922724

Reaction notes

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