3-Pyrimidin-5-ylaniline → N-(3-(5-Pyrimidyl)phenyl)-4-iodo-2-nitroaniline

HRID 581936Notes

Reaction equation

HRID 581936 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([I:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[N:12]1[CH:17]=[C:16]([C:18]2[CH:19]=[C:20]([CH:22]=[CH:23][CH:24]=2)[NH2:21])[CH:15]=[N:14][CH:13]=1>>[N:12]1[CH:17]=[C:16]([C:18]2[CH:19]=[C:20]([NH:21][C:2]3[CH:7]=[CH:6][C:5]([I:8])=[CH:4][C:3]=3[N+:9]([O-:11])=[O:10])[CH:22]=[CH:23][CH:24]=2)[CH:15]=[N:14][CH:13]=1

Participants

3

Reactant 2

HCID 71620493-Pyrimidin-5-ylanilineHCID 145905821-Fluoro-4-iodo-2-nitrobenzene

Product 1

HCID 54493700N-(3-(5-Pyrimidyl)phenyl)-4-iodo-2-nitroanilineYield 79%

Procedure

N-(3-(5-Pyrimidyl)phenyl)-4-iodo-2-nitroaniline (6b) was prepared analogously from 1c (Example 1) and 2b (Example 2). Yield 79%. Mp 214-217° C.

Sources & evidence

ORD record
ord-3baea8f3b1f5440f811b490d4a4ae046
Source dataset
uspto-grants-1999_07
Patent number
US05922724

Reaction notes

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