Formic Acid → HCID 54122290, compound

HRID 581952Notes

Reaction equation

HRID 581952 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:7]=[CH:8][C:9]([NH:13][C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([OH:22])=[O:21])[CH:15]=3)=[C:10]([CH:12]=2)[NH2:11])=[CH:2]1.[CH:23](O)=O>>[C:20]([C:16]1[CH:15]=[C:14]([N:13]2[C:9]3[CH:8]=[CH:7][C:6]([C:3]4[CH:4]=[CH:5][O:1][CH:2]=4)=[CH:12][C:10]=3[N:11]=[CH:23]2)[CH:19]=[CH:18][CH:17]=1)([OH:22])=[O:21]

Participants

3

Reactant 2

HCID 284Formic AcidHCID 54184551HCID 54184551, compound

Product 1

HCID 54122290HCID 54122290, compoundYield 40%

Conditions

Temperature
80 °C

Procedure

To 13r from Example 4 (2.4 g, 8.16 mmol) is added formic acid (25 ml) and the mixture is stirred at 80° C. for 1.5 hours. After cooling the mixture is poured into ice-water. The precipitate is filtered off, washed with methanol and dried to yield 14r (0.89 g, 40%). Mp 272-274° C.

Workup

  1. temperatureAfter cooling the mixture
  2. filtrationThe precipitate is filtered off
  3. washwashed with methanol
  4. customdried

Sources & evidence

ORD record
ord-3065fe134bb540ee953da003d296fd49
Source dataset
uspto-grants-1999_07
Patent number
US05922724

Reaction notes

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